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Importance of a Comprehensive Cancer Treatment Summary The Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers are based on therapeutic exposures received during cancer treatment. Availability of a comprehensive treatment summary, including all therapeutic agents received by the survivor, is presumed. Patients who do not have a comprehensive treatment summary should be instructed to obtain one from the institution s ; where they received their treatment. Ideally, the comprehensive treatment summary should include the following information: Demographics name, sex, date of birth, contact information ; Diagnosis, including site stage, date, and relapse s ; if any Pertinent secondary diagnoses e.g., second malignancy, Down syndrome ; Treatment protocol information, if applicable All chemotherapy agents received during treatment including route of administration for all agents, cumulative doses for alkylators, bleomycin, and anthracyclines, and designation of "high dose" versus "standard dose" for methotrexate and cytarabine ; . Cumulative doses for all other agents should be provided if available. Note: "High dose" methotrexate cytarabine is defined as any single dose 1000 mg m2. "Standard dose" methotrexate cytarabine is defined as all single doses 1000 mg m2. See section 28 of Guidelines for anthracycline isotoxic dose-equivalent conversion. For doses in mg kg, multiply by 30 to obtain equivalent dosing in mg m2 example: 2 mg kg 60 mg m2 ; . Radiation therapy summary, including field s ; , laterality if applicable ; , start stop dates, number of fractions, dose per fraction, boost dose location if applicable ; , total dose in Gy ; , and radiation type. Note: To convert cGy or rads to Gy, divide dose by 100 example: 2400 cGy 2400 rads 24 Gy ; Hematopoietic cell transplant s ; , including type s ; , date s ; , conditioning regimen s ; , and GVHD prophylaxis and or treatment Surgical procedures, including date, site, and laterality if applicable Other therapeutic modalities e.g., biologicals, systemic radiation ; Significant complications late effects with dates of onset resolution Adverse drug reactions allergies Minimum Information Necessary to Generate Patient-Specific Guidelines: In order to generate accurate exposure-based follow-up recommendations from these guidelines, the following information regarding the survivor's diagnosis and treatment is required, at minimum: Survivor's sex Survivor's date of birth Date of cancer diagnosis Date cancer therapy was completed.

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Expertise. Despite outsourcing these activities they are still closely controlled by the company's management, which has the benefit of substantial skills and experience in the clinical development of drugs, the management of research and a high-level of decisionmaking experience in the international pharmaceutical industry. Currently, Metabolic is undertaking a multi-centre Phase 2b study in 300 obese male and female subjects, comparing the weight reduction efficacy of its lead product AOD9604 . Dosing for this trial was completed on 17 September 2004 and previous short term trials up to 1 week ; have indicated that the drug is orally active and well tolerated. The current Phase 2b human trial is a definitive test of the efficacy and safety of the drug over 12 weeks. With a positive result, Metabolic intends to enter into a partnership with a major pharmaceutical company to assist in financing Phase 3 human clinical trials for worldwide marketing approval as a prescription treatment. AOD9604 is a small orally active peptide variant of human growth hormone HGH ; which when administered to humans causes fat reduction via a process known as lipolysis, this is the breakdown of fat into its basic chemical components. Growth hormone levels decrease with age and studies have shown that obese people have lower levels of HGH, making it even harder for them to lose weight. Metabolic hopes that because the product acts directly on the metabolism of fat it will not be dependant on modifying an individual's behaviour such as appetite suppression and the associated side effects and thereby increase its acceptance by patients and doctors. The company's share price has taken a healthy hike north recently, going from about 0.90 to $2.20 by mid November on the back of continuing trial updates. In Australia there are several other companies looking at ways to tackle obesity. These include ChemGenex AGT Biosciences and Adipogen. ChemGenex AGT Biosciences has a high throughput gene discovery facility for the rapid identification of genes involved in diseases such as diabetes and obesity. In 2001 the company discovered the gene Beacon AGT-121 ; , which is more active in animals that will develop obesity, even before the illness has set in. According to ChemGenex, Merck will provide expertise and funding for clinical development and pay $5 million for any target that progresses to phase II clinical trial. With markets worth more than $8 billion dollars year Merck agreed to pay royalties in the vicinity of 5-7% on net sales of any product based on a target supplied by ChemGenex, which may be attractive in the distant future. In the United States there are two main anti-obesity drugs already on the market: Meridia Abbott Laboratories ; and Xenical Roche Laboratories ; . Both have been hampered by some troublesome side effects: high blood pressure in the case of Meridia, and soiling oneself in the case of Xenical Orlistat ; NY Times 7 9 2004 ; . Other competing drugs currently in clinical trials or waiting for approval are: The only anti-obesity drugs in advanced clinical trials are Accomplia and Axokine: Accomplia: Rimonabant to be marketed as Acompoia ; is the lead anti-obesity drug developed by Sanofi Aventis. The company says that it could become one of the industry's once-in-a-decade blockbusters. Many doctors and analysts agree. While doubters note that other promising obesity drugs have proved disappointing and that the company has not completed some crucial tests, Sanofi plans to file for regulatory approval early next year in the United States and alendronate. At site more upcoming events cashing in on the virtual classroom tm ; free teleseminar: 5 secrets to success the internet radio podcast bootcamp request reprint about author email to a friend report problem related books acomplai a ray of hope for millions suffering from obesity by clarence carter send feedback to clarence carter more details about adomplia here.

Synopsis According to data presented at the European Society of Cardiology meeting, Acom0lia rimonabant ; can help patients quit smoking and lose weight. Researchers presented a study involving 1, 507 patients, which showed that obese patients treated for one year on the highest dose of 20 mg per day lost an average of 19 pounds in weight and 3.5 inches of waistline. According to researchers, the drug also increased levels of HDL cholesterol in the blood by 27 and amlodipine.
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