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Abstract: Oral mucositis is a common side effect of cancer therapies, particularly radiation therapy for head and neck cancer and various forms of chemotherapy. It commonly results in severe oral pain that can compromise the duration and success of cancer management. Hospitalizations are common because patients lose the ability to take anything by mouth due to severe pain and must have alimentation supported during this period. Pain management usually requires potent narcotic analgesia. Cancer therapy-related oral mucositis is commonly described as the most significant and debilitating acute complication associated with radiation therapy and chemotherapy. Until recently, cancer therapy-induced oral mucositis was thought to be a process involving the epithelium only. Evidence is building that the process of oral mucositis involves far more than just the epithelium, but includes multiple cellular processes of the submucosa as well. Many strategies have been evaluated to prevent oral mucositis, but the data is confusing since it is often conflicting. Therapy with the growth factor, KGF1, appears promising, as it is the only medication currently approved by the FDA. A multifaceted approach that targets the entire mucositis process will probably be needed to optimize overall prevention. Dr. Redding is Professor, Department of General Dentistry and Director of the Clinical Research Facility at the University of Texas Health Science Center Dental School in San Antonio. Direct correspondence and requests for reprints to him at Department of General Dentistry, University of Texas Health Science Center Dental School, 7703 Floyd Curl Drive, San Antonio, TX 78229; 210-567-3656 phone; 210-567-3662 fax; redding uthscsa . Key words: oral mucositis, cancer, radiation therapy, chemotherapy Submitted for publication 3 31 05; accepted 5 2 05.
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Michelangelo Buonarotti Michelangelo 1475-1564 ; was a sculptor and a painter who lived at the height of the Renaissance period and in many ways embodies the ideas and philosophes of those times. With the Rome Pieta 1500 ; , which depicts Virgin Mary holding the dead Christ on her lap he established his reputation as a sculptor. Next came such timeless works as the famous David 1501-4 ; and the frescoes, which adorn the ceiling of the Sistine Chapel 1508-12 ; . Some of his other works include sculptures for the tomb of Pope Julius II 1513-1516 ; and the Medici Chapel 1524-34 ; . Twenty years after painting the ceiling, Michelangelo returned to the Sistine Chapel to paint the Last Judgment 1534-41 ; Janson, 1997 ; . Just a few days before his death in 1564 Michelangelo was still carving marble. In a poetic fragment he wrote: "No one has full mastery before reaching the end of his art and his life" Vasari, 1986 ; . Art and Anatomy and the Kidney When looking upon Michelangelo's works, it is obvious that the he had great knowledge of the human body. Actually, the artist had a lifelong interest in anatomy. As a young boy, he participated in public dissections, then learned and began to perform his own Eknoyan, 2000 ; . Later in life, he intended to collaborate with Realdo Colombo in the publication of an illustrated book of anatomy. Colombo's book De Re Anatomica was published in 1559, shortly after the author's death, without any illustrations Eknoyan, 1997 ; . Since Michelangelo was in the habit of destroying his drawings, it will never be known whether he made any anatomical drawings for Colombo. During the time of their acquaintance, Colombo became Michelangelo's physician. In 1549, he diagnosed and treated the artist for recurring urolithiasis. Whether Michelangelo suffered from kidney disease before his diagnosis in 1549 cannot be established, though he frequently complained of being in "ill health" in letters to his friends and family. One such letter was written while working on the Sistine Chapel ceiling Eknoyan, 2000 ; . Colombo treated Michelangelo's kidney problems with unknown injections as well as a regimen of special water that had the supposed ability to dissolve urate stones. Despite the treatment, Michelangelo continued to suffer from kidney problems for the rest of his life Eknoyan, 2000 ; . Sistine Chapel Theory A recent article put forth a theory stating that Michelangelo used the shape of the bisected right kidney in designing the mantle of the Creator in his painting of the Separation of Land and Water in the Sistine Chapel ceiling. Computer-assisted removal of God and the cherubs from the painting clearly shows the tunic in the background to be in the shape of the kidney. 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The analysis demonstrate a positive and statistically significant association between alcoholic psychosis morbidity rate and all cause mortality r 0.51; P 0.005 ; , mortality due to alcohol poisoning r 0.77; P 0.001 ; , liver cirrhosis r 0.68; P 0.005 ; , accident and injuries r 0.75; P 0.005 ; , suicides r 0.89; P 0.001 ; , homicides r 0.59; P 0.05 ; , as well as the level of strong spirits consumption per capita r 0.55; P 0.005 ; . Conclusion. The outcome of this study suggests that alcoholic psychosis morbidity rate is considered to be the most reliable indicator of alcohol-related problems magnitudes in the society. This study also adds to the growing body of scientific evidence that a substantial proportion of mortality in Belarus is due to the acute effect of binge drinking. P082 ALCOHOL AND CANNABIS Boni C1 * , Gorwood P1, 2, Pickering P2, Batel P4, Limosin F5, Hamon M3, Ades J1, 2 1 INSERM U 675, Facult de Mdicine Bichat, 75018 Paris, France, 2 CHU Louis Mourier AP-HP, Paris VII ; , 92700 Colombes, France, 3 INSERM U 677, Facult Piti-Salptrire, 75013 Paris, France, 4 CHU Beaujon AP-HP, Paris VII ; , Paris, France, 5 CHU Albert Chennevier AP-HP ; , Paris, France, * Email: claudette.boni bichat.inserm Addictive behaviours are frequently comorbid, a fact that constitute one of its main characteristic. In order to analyse the impact of cannabis use and abuse in a sample of alcohol-dependent patients, we compared 276 subjects, with alcohol-dependence DSM-IV criteria ; , with 187 healthy controls. In the first set of analyses, we showed that patients with comorbid alcohol and cannabis dependence have younger onset of alcohol-dependence, more cognitive impulsivity and suicidal attempts, and more severe alcohol-dependence. In fact, the main characteristic of this subsample is explained by the presence of antisocial personality, which is frequently detected 61% vs 8% ; . We thus focused more specifically on another subsample that used cannabis without being dependent, in order to have a more precise assessment of the impact of cannabis on alcohol-dependence, excluding patients with a double dependence. These patients also have an earlier age at onset, more alcohol-dependence symptoms, and more suicidal attempts, but they specifically have more traffic difficulties and cognitive and memory dysfunctions. Furthermore, they are more frequently depressed odds ratio 4 ; . In global regression analysis, these factors were independent. A recent work attributing the heritability from antisocial personality disorder to alcoholdependence on the one hand 50% ; and cannabis dependence to the other 56% ; shed light on these results. The genetic polymorphism of the CB1 receptor is currently being analysed in order to detect the role of this polymorphism in the interpatient variability of the impact of cannabis use in alcohol-dependent patients. P083 READINESS TO CHANGE STAGE AND THE EFFECT OF A COMPUTERIZED TAILORED BRIEF ADVICE AFTER TRAUMA ON ALCOHOL INTAKE Neumann T * , Neuner B, Weiss-Gerlach E, Spies C Department of Anesthesiology and Intensive Care Medicine, Charit--Universitaetsmedizin Berlin, Campus Charit Mitte, Schumannstrasse 20 21, D-10117 Berlin, Germany, * Email: tim.neumann charite Objective. To determine of the impact of the readiness to change RTC ; stage on the effect a tailored brief advice. Design. Randomized controlled trial. Setting. Emergency department, teaching hospital, Berlin, Germany. Environment that have developed resistance through selection by antibiotic . 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Gerot Pharmazeutika, Dunaj, Gerot Pharmazeutika, Dunaj, Pharmacia & Upjohn S.p.A., Nerviano, Italija za Pharmacia & Upjohn S.p.A., Nerviano, Italija za Chiron Behring GmbH & Co., Marburg Boehringer Ingelheim Pharma KG, Nemcija za Boehringer Ingelheim International GmbH Pharmacio & Upjohn S.A., Luxemburg Pharmacio & Upjohn S.A., Luxemburg.

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No longer recommended in the 2006 update for initial therapy in primary HTN and are now considered to be fourth line agents after angiotensin blocking drugs, calcium channel blockers, and thiazide diuretics. These revised guidelines, which were based on recent clinical trials and meta-analyses, have received considerable press and have caused some to question the role of beta blockers in HTN. This article will summarize the major findings from these recent studies and discuss the ongoing debate regarding the use of beta blockers in primary HTN. RECENT STUDY FINDINGS Drug therapy recommendations for the 2006 NICE update3 were based on evidence from welldesigned, randomized, clinical trials published between July 2004 and December 2005. Only studies directly comparing two or more drugs were included since the intent of the guideline was to aid clinicians with initial drug choices.
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Chemical Properties The molecular weight, macromolecular structure and the degree of crystallisation of PLA vary substantially depending on reaction conditions in the polymerisation process. Of the three possible isomeric forms, poly L-lactic acid ; and poly D-lactic acid ; are both semi-crystalline in nature, and poly meso-lactic acid ; or poly d, l-lactic acid ; is amorphous. By varying the relative content of the stereoforms, the morphology changes from resins that always remain amorphous to amorphous resins that can be crystallized during manufacturing. Racemic PLA - synthesised from petrochemicals - is atactic, i.e. it exhibits no stereochemical regularity of structure, is highly amorphous and has a low glass transition temperature. Amorphous grades of PLA are transparent. The molecular weight of PLA varies from 100, 000 to 300, 000; this range is similar to that for PET 170, 000 to 350, 000 ; . With increasing molecular weight of PLA as for polymers in general ; , strength increases due to the decrease in relative motion of the chains as they become longer. In addition, the resistance to solvents increases and the melt point Tm ; and the glass temperature Tg ; increase. The melt viscosity increases and the ease of fabrication moulding, extrusion and shaping ; decreases McGraw-Hill, 1997 ; . Physical Properties The specific gravity of PLA 1.25 g cm3 ; is lower than that of PET 1.34 g cm3 ; , but higher than HIPS 1.05 g cm3 ; and also higher to many other conventional polymers which have specific gravity in the range of 0.8 to 1.1. PLA is reasonably transparent and has high gloss and low haze. The optical properties of PLA are sensitive to additive and fabrication effects Gruber and O'Brien, 2002 in particular, since the lower the degree of crystallinity the higher the transparency, highly crystalline PLA has poor optical properties. Mechanical Properties PLA has good mechanical properties, performing well compared to standard thermoplastics. It has low impact strength, comparable to non-plasticised PVC. The hardness, stiffness, impact strength and elasticity of PLA, important for applications such as beverage flasks, are similar to values for PET. Oriented PLA film can hold a crease or fold or retain a twist, properties inherent to paper and foil but usually lacking in plastic films. These properties, in combination with PLA's high flexular modulus and high clarity, are comparable with those of cellophane films Gruber and O'Brien, 2002 ; . Thermal Properties PLA has a relatively low glass transition temperature ~ 60 C ; and degrades quickly above this temperature in high moisture conditions. Due to its low Vicat softening point, PLA is less not suitable for filling at elevated temperatures similarly to PET ; . PLA's low softening point also poses a problem for warehousing of products and use in automobiles. On the other hand, PLA's low heat deflection temperature HDT ; and high heat seal strength lead to good performance in film sealing. According to Cargill Dow, the melting point for PLA ranges from 120-170 C; however, Treofan quotes a much lower figure of 85 C Treofan, 2003. ADAGEN Misc Products ADALAT CC Cardiac Drugs ADDERALL Autonomic Drugs ADDERALL XR Autonomic Drugs ADENOCARD Cardiac Drugs ADENOCARD IV Cardiac Drugs adenosine Cardiac Drugs ADENOSINE Cardiac Drugs adenosine Cardiovascular ADOXA Antiinfectives ADOXA PAK Antiinfectives ADRENALIN CHLORIDE NASAL Eent Preps ADVAIR DISKUS Antiasthmatics ADVICOR Cardiovascular AEROBID Hormones AEROBID-M Hormones AEROKID Cough Cold Preps AGENERASE Antiinfectives Misc. AGGRENOX Blood AGRYLIN Blood AH-CHEW Cough Cold Preps AH-CHEW D Cough Cold Preps AH-CHEW II Cough Cold Preps AKINETON Antiparkinson Drugs AKNE-MYCIN Skin Preps ALA-CORT Skin Preps ALAMAST Eent Preps ALA-QUIN Skin Preps ALA-SCALP HP Skin Preps ALA-TET Antiinfectives ALBA-3 Eent Preps ALBALON Eent Preps ALBATUSSIN SR SENIOR Cough Cold Preps ALBENZA Antiinfectives Misc.

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