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6Section 1782 has been used on many occasions by foreign litigants seeking assistance of the U.S. courts. For example, in South Carolina Insurance Co. v. Assurantie Maatschappij de Zeven Provincien NV.14, the defendants, prior to filing a statement of defence in England, brought a petition in the U.S., pursuant to section 1782 of the United States Code, seeking among other things, an order for pre-trial discovery of documents. The plaintiffs sought injunctive relief in England to restrain the defendants from proceeding in the U.S. An injunction was issued by the British court. The injunction was upheld by the Court of Appeal but set aside in the House of Lords. The House of Lords rejected the Court of Appeal's reasoning that the English court must retain control of its own process, finding instead that the defendants' conduct in starting U.S. proceedings with a view to using their pre-trial discovery procedure did not amount to unconscionable conduct. The House of Lords refused to restrain the defendants from lawful evidence gathering, finding that the defendants had neither invaded or threatened to invade the respondents' legal or equitable rights, or behaved in an unconscionable manner. The House of Lords noted that in civil proceedings the court did not, in general, exercise any control over the manner in which a party obtained evidence: I cannot see that the defendants, by seeking to exercise a right potentially available to them under the Federal law of the United States, have in any way departed from, or interfered with, the procedure of the English court. All they have done is what any party preparing his case in the High Court here is entitled to do, namely to try to obtain in a foreign country, by means lawful in that country, documentary evidence which they believe that they need in order to prepare and present their case.15 Typically, section 1782 of the U.S. Code has been used by Canadian litigants seeking the assistance of U.S. courts to obtain discovery of a person who, although discoverable in Canadian litigation, is not willing or available to attend. For example, in Penty v. Law Society of British Columbia16 the Law Society sought, pursuant to section 1782, to take testimony from a U.S. resident, Craig Clymore, who filed a complaint against the plaintiff. Mr. Clymore was incarcerated in a penitentiary in Oklahoma at the time and the plaintiff sought to prevent the Law Society from taking his testimony arguing that the Law Society had no jurisdiction to conduct discipline hearings outside provincial boundaries. The British Columbia Court of Appeal found in favour of the Law Society holding that.
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For all the physiological experiments, material of transgenic plants was used that showed more than twofold higher GR activity compared to nontransgenic plant material. Such elevated GR activity of transgenic plants had no significant P 0.05 ; effect on the total glutathione content of the leaves or the reduction state of the glutathione pool of these plants Table I ; . Similarly, transgenic plants had identical light saturation curves for photosynthesis when compared to nontransgenic plants Fig. 8 ; . In all cases, the quantum yield and the maximum photosynthetic rate were unchanged. The effects of oxidative conditions on GR activity were measured under in vivo and in vitro conditions. To study oxidation in vitro, GR in the soluble fraction of leaf extracts of either transgenic or nontransgenic plants was subjected to reducing or oxidizing conditions. Under both conditions, the changes in activity of GR were rather small Fig. 9 ; . Exposure to DTT caused some inhibition of GR activity in both transgenic and nontransgenic plants. GR is known to become inactive when forced to accept four electrons and form additional covalent bonds in the active site of the enzyme, and the inactivation described here may be related to this. In contrast, NADP-malate dehydrogenase, which is a thiol-modulated enzyme that can be activated by DTT, was substantially activated under these conditions Fig. 9A ; . H202 treatment had no effect on the GR activity of nontransgenic plants, whereas GR activity of transgenic plants decreased slowly with the time of exposure to H202. For comparison, the NADP-malate dehydrogenase remained largely inactive under these conditions Fig. 9B ; . The effect of oxidation in vivo was studied by incubation of leaf discs in the presence of the herbicide methylviologen. Extractable GR activity increased significantly P 0.05 ; following exposure to 5 uM methylviologen in the dark in both transgenic and nontransgenic plants Table IIA ; . Treatment of plants with methylviologen concentrations above 10 Mm resulted in a severe loss of GR activity in the light but not in the dark data not shown ; . Because the overall absolute increase in activity in transgenic plants after methylviologen treatment was significantly higher P 0.05 ; than that of nontransgenic controls alone, bacterial GR activity must have also increased following exposure to methylviologen Table II ; . We did not observe a comparable increase in , 3-glucuronidase activity when leaf discs of transgenic tobacco plants carrying a 35S-gus-poly A ; 12 ; fusion, expressing the gene for , 3-glucuronidase 15 ; , were exposed under identical conditions to methylviologen data not shown ; . Thus, the effect found for GR appears to be rather specific. In a similar fashion to the treatment with methylviologen and axid, because atarax antihistamine. 1. Care homes use `chemical cosh' on the elderly. London: Daily Telegraph, 23 July 2001. 2. Royal College of Physicians. Medication for Older People second edition ; . Report of a Working Party. London: Royal College of Physicians, 1997. 3. Reilly JG, Ayis SA, Ferrier IN, Jones SJ, Thomas SHL. QT interval abnormalities and psychotropic drug therapy in psychiatric patients. Lancet 2000; 355: 104852. Hughes CM, Lapane KL, Mor V et al. The impact of legislation on psychotropic drug use in nursing homes: a crossnational perspective. J Geriatr Soc 2000; 48: 9317!

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