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Jinsu Kim, Jae Sung Lee, June-Key Chung, Myung Chul Lee, Dong Soo Lee Purpose: Detectable size of the lesions in oncology PET studies is determined by the physical factors, such as the fraction of count recovery within the lesion and background variability. In this study, relationship between these parameters and reconstruction method in 2D 3D PET acquisition was investigated for Siemens ECAT EXACT 47 PET scanner. Methods: NEMA IEC body phantom which consisted of 2 large cold spheres inner diameter: 37 and 28 mm ; and 4 small hot spheres 22, 17, 13, and 10 mm ; were filled with F-18 solution. The concentration of the background activity in the phantom was 5.3 kBq mL and those of hot spheres were 4 and 8 times of the background. PET data were acquired for 7.5 min with coincidence window of 12 ns and energy window of 250~650 keV, and reconstructed using OSEM and FBP algorithms. The measurement was repeated 3 times for each region to background ratio 8: 1, 4: ; PET data acquisition mode. Multiple ROIs were drawn on every hot and cold spheres and the background of the phantom: 12 background ROIs were drawn in the central slice and in slices 10 and 20 mm away. Hot sphere contrast recovery coefficient CRC ; , cold sphere CRC and background variability were calculated according to the equations defined in NEMA NU2-2001 standard. Results: The CRC and variability for the different sphere sizes, reconstruction method, region to background ratio in 2D 3D PET acquisition mode were calculated. CRC and variability was similar regardless of region to background ratio. Background variability of 3D was lower than that of 2D. However, CRC was similar in 2D 3D. Conclusion: The results suggest that background variability, not the recovery coefficient, can be improved by increasing count rate in order to enhance the lesion detectability in the oncology PET studies and soma.
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